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Topamax comopiramate comes as a tablet and a sprinkle capsule to take by mouth. It is usually administered with or without food twice a day, morning and night. Take topiramate around the same times every day. Topiramate tablets have a bitter taste and lose their effectiveness quickly when broken, so you have to swallow them whole. No debt, chew or crush them. As with other drugs of this class, patients should start with a low dose and slowly taper up to therapeutic levels. The daily dose should be taken in two doses approximately 12 hours. The interruption of this medication, it is essential to reduce slowly rather than stop abruptly.